Belgian Cancer Registry on FHIR
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: BCR Molecular Marker - XML Representation

Draft as of 2026-05-04

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<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="bcr-molecular-marker"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: CodeSystem bcr-molecular-marker</b></p><a name="bcr-molecular-marker"> </a><a name="hcbcr-molecular-marker"> </a><p>This case-sensitive code system <code>https://www.ehealth.fgov.be/standards/fhir/registries/bcr/CodeSystem/bcr-molecular-marker</code> defines the following codes:</p><table class="codes"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style="white-space:nowrap">ER<a name="bcr-molecular-marker-ER"> </a></td><td>Estrogen receptor</td><td>Oestrogeen receptor status (ER).</td></tr><tr><td style="white-space:nowrap">PR<a name="bcr-molecular-marker-PR"> </a></td><td>Progesterone receptor</td><td>Progesteron receptor status (PR).</td></tr><tr><td style="white-space:nowrap">HER2-IHC<a name="bcr-molecular-marker-HER2-IHC"> </a></td><td>HER2 IHC score</td><td>HER2 IHC score (0 / 1+ / 2+ / 3+).</td></tr><tr><td style="white-space:nowrap">HER2-IHC-ISH<a name="bcr-molecular-marker-HER2-IHC-ISH"> </a></td><td>HER2 status (IHC + ISH combined)</td><td>HER2 status op basis van IHC en ISH.</td></tr><tr><td style="white-space:nowrap">BRCA1-2<a name="bcr-molecular-marker-BRCA1-2"> </a></td><td>BRCA1/2</td><td>BRCA1/2 mutation status.</td></tr><tr><td style="white-space:nowrap">CHEK2<a name="bcr-molecular-marker-CHEK2"> </a></td><td>CHEK2</td><td>CHEK2 mutation status. Spelled 'CHECK2' on the source form.</td></tr><tr><td style="white-space:nowrap">PALB2<a name="bcr-molecular-marker-PALB2"> </a></td><td>PALB2</td><td>PALB2 mutation status.</td></tr><tr><td style="white-space:nowrap">ATM<a name="bcr-molecular-marker-ATM"> </a></td><td>ATM</td><td>ATM mutation status.</td></tr><tr><td style="white-space:nowrap">PIK3CA<a name="bcr-molecular-marker-PIK3CA"> </a></td><td>PIK3CA</td><td>PIK3CA mutation status. Spelled 'PIKCA3' on the source form.</td></tr><tr><td style="white-space:nowrap">KI67<a name="bcr-molecular-marker-KI67"> </a></td><td>Ki-67 before systemic therapy</td><td>Ki-67 vóór systemische therapie. Result is expressed as a percentage.</td></tr><tr><td style="white-space:nowrap">OTHER<a name="bcr-molecular-marker-OTHER"> </a></td><td>Other</td><td>Other marker — free-text marker name expected.</td></tr></table></div>
  </text>
  <url
       value="https://www.ehealth.fgov.be/standards/fhir/registries/bcr/CodeSystem/bcr-molecular-marker"/>
  <version value="0.1.0"/>
  <name value="BCRMolecularMarker"/>
  <title value="BCR Molecular Marker"/>
  <status value="draft"/>
  <experimental value="true"/>
  <date value="2026-05-04T06:30:16+00:00"/>
  <publisher value="eHealth Platform Belgium"/>
  <contact>
    <name value="eHealth Platform Belgium"/>
    <telecom>
      <system value="url"/>
      <value value="https://www.ehealth.fgov.be"/>
    </telecom>
    <telecom>
      <system value="email"/>
      <value value="info@ehealth.fgov.be"/>
    </telecom>
  </contact>
  <description
               value="Molecular markers listed on Bijlage 55 vervolg 1. The form spells PIK3CA as 'PIKCA3'; the canonical gene symbol is preserved here."/>
  <jurisdiction>
    <coding>
      <system value="urn:iso:std:iso:3166"/>
      <code value="BE"/>
      <display value="Belgium"/>
    </coding>
  </jurisdiction>
  <caseSensitive value="true"/>
  <content value="complete"/>
  <count value="11"/>
  <concept>
    <code value="ER"/>
    <display value="Estrogen receptor"/>
    <definition value="Oestrogeen receptor status (ER)."/>
  </concept>
  <concept>
    <code value="PR"/>
    <display value="Progesterone receptor"/>
    <definition value="Progesteron receptor status (PR)."/>
  </concept>
  <concept>
    <code value="HER2-IHC"/>
    <display value="HER2 IHC score"/>
    <definition value="HER2 IHC score (0 / 1+ / 2+ / 3+)."/>
  </concept>
  <concept>
    <code value="HER2-IHC-ISH"/>
    <display value="HER2 status (IHC + ISH combined)"/>
    <definition value="HER2 status op basis van IHC en ISH."/>
  </concept>
  <concept>
    <code value="BRCA1-2"/>
    <display value="BRCA1/2"/>
    <definition value="BRCA1/2 mutation status."/>
  </concept>
  <concept>
    <code value="CHEK2"/>
    <display value="CHEK2"/>
    <definition
                value="CHEK2 mutation status. Spelled 'CHECK2' on the source form."/>
  </concept>
  <concept>
    <code value="PALB2"/>
    <display value="PALB2"/>
    <definition value="PALB2 mutation status."/>
  </concept>
  <concept>
    <code value="ATM"/>
    <display value="ATM"/>
    <definition value="ATM mutation status."/>
  </concept>
  <concept>
    <code value="PIK3CA"/>
    <display value="PIK3CA"/>
    <definition
                value="PIK3CA mutation status. Spelled 'PIKCA3' on the source form."/>
  </concept>
  <concept>
    <code value="KI67"/>
    <display value="Ki-67 before systemic therapy"/>
    <definition
                value="Ki-67 vóór systemische therapie. Result is expressed as a percentage."/>
  </concept>
  <concept>
    <code value="OTHER"/>
    <display value="Other"/>
    <definition value="Other marker — free-text marker name expected."/>
  </concept>
</CodeSystem>